SMNDC1 anticorps

N° du produit ABIN7504151

Cet anticorps Souris Monoclonal détecte spécifiquement SMNDC1 dans FACS et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour SMNDC1 anticorps (ABIN7504151)

Antigène: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMNDC1 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-SMNDC1 anticorps

Specificité: SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human SMNDC1 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Positive Control: HeLa or HepG2 cells.

Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Date de péremption: 24 months

Détails sur SMNDC1

Antigène: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Autre désignation: SMNDC1

Sujet: 30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMNR, SPF30, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing protein 1, Survival of motor neuron related splicing factor 30,SMNDC1
Cellular localisation: Nucleus. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.

Poids moléculaire: 30kDa

ID gène: 10285, 632093

UniProt: O75940