SMNDC1 anticorps

N° du produit ABIN7126174

Détail du produit anti-SMNDC1 anticorps

Antigène: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMNDC1 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Specificité: SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human SMNDC1 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or HepG2 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur SMNDC1

Antigène: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Autre désignation: SMNDC1 (SMNDC1 Produits)

Synonymes: anticorps smnr, anticorps spf30, anticorps SMNDC1, anticorps SMNR, anticorps SPF30, anticorps TDRD16C, anticorps wu:fb37h07, anticorps wu:fc23a07, anticorps 2410004J23Rik, anticorps 4933440I19Rik, anticorps survival motor neuron domain containing 1, anticorps smndc1, anticorps SMNDC1, anticorps Bm1_41545, anticorps Smndc1

Sujet: 30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMNR, SPF30, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing protein 1, Survival of motor neuron related splicing factor 30,SMNDC1
Cellular localisation: Nucleus. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.

Poids moléculaire: 30kDa

ID gène: 10285, 632093

UniProt: O75940