E2F6 anticorps
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- Antigène Voir toutes E2F6 Anticorps
- E2F6 (E2F Transcription Factor 6 (E2F6))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp E2F6 est non-conjugé
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Application
- Immunofluorescence (IF), Flow Cytometry (FACS)
- Specificité
- The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1and S phases of the cell cycle. E2F-1 is a member of a broader family of transcriptional regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex.
- Réactivité croisée (Details)
- Human
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human E2F6 protein
- Isotype
- IgG2b
- Top Product
- Discover our top product E2F6 Anticorps primaire
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- Indications d'application
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or Jurkat cells.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- E2F6 (E2F Transcription Factor 6 (E2F6))
- Autre désignation
- E2F6 (E2F6 Produits)
- Synonymes
- anticorps E2F-6, anticorps AI462434, anticorps E2F6b, anticorps EMA, anticorps E2F transcription factor 6, anticorps E2F6, anticorps E2f6
- Sujet
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EMA, MGC111545,E2F6
Cellular localisation: Nucleus - Poids moléculaire
- 35kDa
- ID gène
- 1876, 603093
- UniProt
- O75461
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