Endoglin anticorps

N° du produit ABIN7126335

L’anticorps Souris Monoclonal anti-Endoglin a été validé pour FACS, ELISA, IF, Func et Coat. Il convient pour détecter Endoglin dans des échantillons de Humain.

Aperçu rapide pour Endoglin anticorps (ABIN7126335)

Antigène: Endoglin (ENG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Endoglin est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Functional Studies (Func), Coating (Coat)

Détail du produit anti-Endoglin anticorps

Specificité: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Réactivité croisée (Details): Human, Monkey, Horse, Pig and Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), Functional Assays (order antibody without BSA and azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (2-4 μg/mL) Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, A431 or HL-60 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Endoglin

Antigène: Endoglin (ENG)

Autre désignation: ENG

Sujet: CD105, END, Endoglin, Eng, HHT1, S-endoglin,Endoglin / CD105 (Angiogenesis Marker)
Cellular localisation: Cell Surface

Poids moléculaire: 80kDa (Monomer), 160kDa (Homodimer)

ID gène: 2022, 76753

UniProt: P17813