GCET2 anticorps (AA 1-200)

N° du produit ABIN7126453

Cet anticorps anti-GCET2 Monoclonal Souris (Clone HGAL-830) (ABIN7126453) détecte spécifiquement GCET2 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GCET2 anticorps (AA 1-200) (ABIN7126453)

Antigène: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GCET2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: HGAL-830

Détail du produit anti-GCET2 anticorps

Épitope: AA 1-200

Fonction: HGAL (Human Germinal Center Associated Lymphoma Marker) Antibody

Specificité: Recognizes a protein of kDa, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (178 Amino acid residues from around aa1-200) of human HGAL protein

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Daudi, Raji or U266 cells. Human lymphocytes. Human lymph node, tonsil or testis.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur GCET2

Antigène: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Autre désignation: GCSAM

Sujet:

GCAT2, GCET2 germinal center expressed transcript 2, Germinal center associated lymphoma (hGAL), Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated signaling and motility protein

Daudi, Raji or U266 cells. Human lymphocytes. Human lymph node, tonsil or testis.

Poids moléculaire: 21kDa

ID gène: 257144, 49614

UniProt: Q8N6F7