AMH anticorps (AA 460-560)

N° du produit ABIN7126471

Cet anticorps anti-AMH est un anticorps Souris Monoclonal détectant AMH dans WB et IHC (f). Adapté pour Humain.

Aperçu rapide pour AMH anticorps (AA 460-560) (ABIN7126471)

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AMH est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Détail du produit anti-AMH anticorps

Épitope: AA 460-560

Specificité: The transforming growth factor i²(TGFi²) superfamily is composed of numerous growth and differentiation factors, including TGFi²1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin i±,i²-A, i²-B and i²-C, Lefty and Nodal. Members of the TGFi²superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Réactivité croisée (Details): Human, mouse, sheep and baboon.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human or mouse ovary tissue.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur AMH

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Autre désignation: AMH

Sujet: Muellerian inhibiting factor (MIF),Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS)
Cellular localisation: Secreted

Poids moléculaire: 70kDa (reduced), 140kDa (nonreduced)

ID gène: 268, 112432

Pathways: Negative Regulation of Hormone Secretion