Recombinant INSM1 anticorps (N-Term)

N° du produit ABIN7126595

Cet anticorps Lapin Monoclonal détecte spécifiquement INSM1 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant INSM1 anticorps (N-Term) (ABIN7126595)

Antigène: INSM1 (Insulinoma-Associated 1 (INSM1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp INSM1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: INSM1-6286R

Détail du produit anti-INSM1 anticorps

Épitope: AA 81-125, N-Term

Fonction: Recombinant INSM1 (Pan-Neuroendocrine Marker) Antibody

Specificité: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogène: Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1

Isotype: IgG, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human pancreas or neuroendocrine tumor.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur INSM1

Antigène: INSM1 (Insulinoma-Associated 1 (INSM1))

Autre désignation: INSM1

Sujet:

IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1

Human pancreas or neuroendocrine tumor.

Poids moléculaire: 58kDa

ID gène: 3642, 89584

UniProt: Q01101