Keratin 6B anticorps

N° du produit ABIN7126618

Détail du produit anti-Keratin 6B anticorps

Antigène: Keratin 6B (KRT6B)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Keratin 6B est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Réactivité croisée (Details): Human and Mouse.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human KRT6B protein

Isotype: IgG2a

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Tonsil or basal cell carcinoma

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Keratin 6B

Antigène: Keratin 6B (KRT6B)

Autre désignation: KRT6B (KRT6B Produits)

Synonymes: anticorps CK-6B, anticorps CK6B, anticorps K6B, anticorps KRTL1, anticorps PC2, anticorps KRT6C, anticorps KRT6A, anticorps KRT6B, anticorps BB144589, anticorps Krt2-6b, anticorps mK6[b], anticorps KERIV, anticorps keratin 6B, anticorps keratin, type II cytoskeletal 5, anticorps keratin, type II cytoskeletal 6B, anticorps KRT6B, anticorps Krt6b, anticorps LOC100566088, anticorps LOC100593588

Sujet: CK6B, Keratin Type II Cytoskeletal 6B, KRT6B,Cytokeratin 6B (KRT6B) (Basal Cell Marker)
Cellular localisation: Cytoplasmic

Poids moléculaire: 56kDa

ID gène: 3854, 700779

UniProt: P04259