Cytokeratin 13 anticorps

N° du produit ABIN7126625

Cet anticorps Souris Monoclonal détecte spécifiquement Cytokeratin 13 dans WB, IF et IHC (f). Il présente une réactivité envers Lapin.

Aperçu rapide pour Cytokeratin 13 anticorps (ABIN7126625)

Antigène: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Reactivité: Lapin

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cytokeratin 13 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Détail du produit anti-Cytokeratin 13 anticorps

Specificité: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs)that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with Cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.

Réactivité croisée (Details): Human, mouse, rat and rabbit.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: esophageal keratins of rabbit origin

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or A431 cells. Skin or Squamous cell carcinoma

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Cytokeratin 13

Antigène: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Autre désignation: KRT13

Sujet: CK13, Cytokeratin-13, Keratin Type I Cytoskeletal 13, Keratin-13, KRT13, Type I Cytoskeletal 13, WSN2,Cytokeratin 13 (Non-Keratinized Squamous Epithelial Marker)
Cellular localisation: Cytoplasmic

Poids moléculaire: 52kDa

ID gène: 3860, 654550

UniProt: P13646