Recombinant Ki-67 anticorps (AA 2293-2478)

N° du produit ABIN7126698

Détail du produit anti-Ki-67 anticorps

Antigène: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Type d'anticorp: Recombinant Antibody

Épitope: AA 2293-2478

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Ki-67 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 2293-2478) of human Ki67 protein (exact sequence is proprietary)

Isotype: IgG

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Any actively proliferating cells. Human skin, tonsil or lymph node.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Ki-67

Antigène: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Autre désignation: MKI67 (MKI67 Produits)

Synonymes: anticorps MKI67, anticorps kia, anticorps mki67, anticorps MGC132156, anticorps D630048A14Rik, anticorps Ki-67, anticorps Ki67, anticorps KIA, anticorps MIB-1, anticorps marker of proliferation Ki-67, anticorps marker of proliferation Ki-67 L homeolog, anticorps marker of proliferation Ki-67 S homeolog, anticorps antigen identified by monoclonal antibody Ki 67, anticorps antigen identified by monoclonal antibody Ki-67, anticorps nucleolar protein interacting with the FHA domain of MKI67, anticorps MKI67, anticorps mki67, anticorps mki67.L, anticorps mki67.S, anticorps Mki67, anticorps NIFK

Sujet: KI-67, Ki67, KI-67 Antigen (KIA), MKI67, Proliferation related Ki-67 antigen,Ki-67 (Proliferating Cell Marker)
Cellular localisation: Nuclear

Poids moléculaire: 345kDa and 395kDa

ID gène: 4288, 689823

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process