PBX1 anticorps

N° du produit ABIN7126761

Détail du produit anti-PBX1 anticorps

Antigène: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PBX1 est non-conjugé

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Peptide (BP), Coating (Coat)

Specificité: Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1,19)(q23,p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92 % and 94 % respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human PBX1 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Expressed in all tissues except in cells of the B and T lineage.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur PBX1

Antigène: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Autre désignation: PBX1 (PBX1 Produits)

Synonymes: anticorps fi29e01, anticorps pbx1b, anticorps wu:fi29e01, anticorps zgc:55265, anticorps 2310056B04Rik, anticorps AI848790, anticorps AU015730, anticorps D230003C07Rik, anticorps Pbx-1, anticorps Pbx1a, anticorps Pbx1b, anticorps PBX1A, anticorps Xpbx1, anticorps Xpbx1b, anticorps PBX homeobox 1, anticorps pre-B-cell leukemia homeobox 1a, anticorps pre B cell leukemia homeobox 1, anticorps pre-B-cell leukemia homeobox 1 S homeolog, anticorps PBX1, anticorps pbx1a, anticorps Pbx1, anticorps pbx1.S

Sujet: DKFZp686B09108, Homeobox protein PBX 1, Homeobox protein PBX1, Homeobox protein PRL, Pbx1, Pre B cell leukemia homeobox 1, Pre B cell leukemia transcription factor 1, Pre-B-cell leukemia transcription factor 1, PRL,PBX1 / PRL (Transcription Factor)
Cellular localisation: Nucleus.

Poids moléculaire: 86.1kDa

ID gène: 5087, 557097

UniProt: P40424