PMS1 anticorps

N° du produit ABIN7126799

Cet anticorps Souris Monoclonal détecte spécifiquement PMS1 dans ELISA, IP, FACS, IF et ISt. Il présente une réactivité envers Humain.

Aperçu rapide pour PMS1 anticorps (ABIN7126799)

Antigène: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PMS1 est non-conjugé

Application: ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF), Immunostaining (ISt)

Détail du produit anti-PMS1 anticorps

Specificité: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human PMS1 protein

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: ELISA (concentration is assay dependent), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, U-251 MG or CACO-2 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur PMS1

Antigène: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Autre désignation: PMS1

Sujet: DNA mismatch repair protein PMS1, HNPCC3, hPMS1, Human homolog of yeast mutL, PMS1 postmeiotic segregation increased 1 (S. cerevisiae), PMS1 protein homolog 1, PMSL1, Rhabdomyosarcoma antigen MU RMS 40.10B / 40.10E,PMS1
Cellular localisation: Nucleus. Nuclear bodies.

Poids moléculaire: 105.8kDa

ID gène: 5378, 111749

UniProt: P54277