TREM2 anticorps (AA 1-200)

N° du produit ABIN7126804

Cet anticorps anti-TREM2 est un anticorps Souris Monoclonal détectant TREM2 dans IHC (f). Adapté pour Humain.

Aperçu rapide pour TREM2 anticorps (AA 1-200) (ABIN7126804)

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM2 est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: TREM2-7210

Détail du produit anti-TREM2 anticorps

Épitope: AA 1-200

Specificité: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), known as Nasu-Hakola disease , is a recessively inherited disease where individuals display early-onset progressive dementia and bone cysts, which leads to death. Mutations in TYROBP (DAP12), which codes for a membrane receptor component in natural-killer and myeloid cells and mutations in triggering receptor expressed on myeloid cells-2 (TREM-2), correlate well to the pathology of PLOSL. TREM-2 is a cell surface receptor on human monocyte-derived dendritic cells that forms a receptor signaling complex with DAP12 and triggers activation of the immune response in macrophages and dendritic cells (DC). The TREM-2/DAP12 complex is a molecular promoter of upregulation of CC chemokine receptor 7, partial DC maturation, and DC survival through activation of protein tyrosine kinases and extracellular signal regulated kinase. The human chronic inflammatory TREM-2 gene maps to chromosome 6p21.1 and encodes a 230 amino acid protein.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human TREM2 protein (exact sequence is proprietary)

Isotype: IgG

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human small intestine, ovary or placenta.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur TREM2

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Autre désignation: TREM2

Sujet: TREM2, TREM2a, TREM2b, TREM2c, Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2,TREM2 (Triggering Receptor Expressed On Myeloid Cells 2)
Cellular localisation: Cell surface. Secreted.

Poids moléculaire: 40kDa (glycosylated), 26kDa (deglycosylated)

ID gène: 54209, 435295

UniProt: Q9NZC2