MBNL3 anticorps

N° du produit ABIN7126833

Détail du produit anti-MBNL3 anticorps

Antigène: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MBNL3 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.

Réactivité croisée (Details): Human

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human MBNL3 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or MCF7 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur MBNL3

Antigène: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Autre désignation: MBNL3 (MBNL3 Produits)

Synonymes: anticorps A530038J18Rik, anticorps AI661274, anticorps CHCR, anticorps E430034C16Rik, anticorps MBLX, anticorps MBLX39, anticorps MBXL, anticorps mbxl, anticorps RGD1565834, anticorps muscleblind like splicing regulator 3, anticorps muscleblind like splicing factor 3, anticorps Muscleblind-like protein 3-like, anticorps muscleblind-like splicing regulator 3, anticorps MBNL3, anticorps Mbnl3, anticorps mbnl3

Sujet: CHCR, Cys3His CCG1 required protein, MBLX, MBLX39, Muscleblind like protein 3, Muscleblind like splicing regulator 3, Muscleblind-like X-linked protein, Protein HCHCR, RP23-98P13.1,MBNL3
Cellular localisation: Nucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.

Poids moléculaire: 39kDa

ID gène: 55796

UniProt: Q9NUK0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development