SLAMF7 anticorps (AA 249-335)

N° du produit ABIN7126855

Cet anticorps anti-SLAMF7 est un anticorps Souris Monoclonal détectant SLAMF7 dans IHC (f). Adapté pour Humain.

Aperçu rapide pour SLAMF7 anticorps (AA 249-335) (ABIN7126855)

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SLAMF7 est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Détail du produit anti-SLAMF7 anticorps

Épitope: AA 249-335

Specificité: CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLC and PI 3K. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human SLAMF7 protein (around aa 249-335) (exact sequence is proprietary)

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human tonsil tissue.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur SLAMF7

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Autre désignation: SLAMF7

Sujet: 19A, 19A24 protein, CD2 like receptor activating cytotoxic cells, CD2 subset 1, CRACC, CS1, Membrane protein FOAP 12, Novel LY9 (lymphocyte antigen 9) like protein, Protein 19A, SLAM family member 7,SLAMF7 / CS1 / CD319
Cellular localisation: Cell surface

Poids moléculaire: 37kDa

ID gène: 57823, 517265

UniProt: Q9NQ25