TARBP2 anticorps

N° du produit ABIN7126994

Cet anticorps anti-TARBP2 est un anticorps Souris Monoclonal détectant TARBP2 dans WB, IF et FACS. Adapté pour Humain.

Aperçu rapide pour TARBP2 anticorps (ABIN7126994)

Antigène: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TARBP2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-TARBP2 anticorps

Specificité: TRBP2, also known as TARBP2 (trans-activation-responsive (HIV-1) RNA binding protein 2), TRBP1 or TRBP, is a nuclear protein that contains three DRBM (double-stranded RNA-binding) domains. TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. The third DRBM motif in the C-terminus of human TRBP2 can interact with and inhibit PKR activity, thereby increasing HIV-1 long terminal repeat (LTR) expression. In addition, TRBP2 functions as a component of a Dicer-containing complex and associates with the catalytic subunit of the RNA-induced silencing complex (RISC), namely eIF2C2. TRBP2 is essential for Dicer stability and the proper assembly of RISC. This suggests that TRBP2, in association with Dicer, plays an important role in the processing of miRNAs (microRNAs).

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human TARBP2 protein

Isotype: IgG2a

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: MCF-7 or HeLa cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur TARBP2

Antigène: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Autre désignation: TARBP2

Sujet: LOQS, Prbp, RISC loading complex subunit TARBP2, TAR (HIV 1) RNA binding protein 2, TAR RNA Binding Protein 2, TARBP2 RISC loading complex RNA binding subunit, Trans-activation-responsive RNA-binding protein, TRBP, TRBP1,TRBP2 / TARBP2
Cellular localisation: Cytoplasm. Cytoplasm > perinuclear region. Nucleus.

Poids moléculaire: 45kDa

ID gène: 6895, 326

UniProt: Q15633

Pathways: Regulatory RNA Pathways, Ribonucleoprotein Complex Subunit Organization