TIA1 anticorps (AA 279-380)

N° du produit ABIN7127001

Détail du produit anti-TIA1 anticorps

Antigène: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Épitope: AA 279-380

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Specificité: TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human TIA1 fragment of 102 amino acid residues (aa279-380)

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (0.5-1 μg/million cells in 0.1ml), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL for 60 minutes at RT),Optimal dilution for a specific application should be determined.

Positive_Control: HepG2, PC3 or HeLa cells. Human tonsil.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur TIA1

Antigène: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Autre désignation: TIA1 (TIA1 Produits)

Synonymes: anticorps tia1, anticorps 2310050N03Rik, anticorps AI256674, anticorps TIA-1, anticorps mTIA-1, anticorps WDM, anticorps TIAL1, anticorps TIAR, anticorps tia-1, anticorps nucleolysin TIA-1 isoform p40, anticorps hypothetical protein, anticorps nucleolysin TIAR, anticorps nucleolysin tia-1, anticorps nucleolysin TIA-1, anticorps cytotoxic granule-associated RNA binding protein 1, anticorps TIA1 cytotoxic granule associated RNA binding protein, anticorps TIA1 cytotoxic granule-associated RNA binding protein, anticorps TIA1 cytotoxic granule-associated RNA binding protein L homeolog, anticorps PTRG_10065, anticorps PGTG_08590, anticorps LOC5568274, anticorps CpipJ_CPIJ013665, anticorps VDBG_07004, anticorps MGYG_03339, anticorps Tsp_15456, anticorps tia1, anticorps Tia1, anticorps TIA1, anticorps tia1.L

Sujet: Cytotoxic granule associated RNA binding protein 1, mTIA-1, Nucleolysin TIA1 isoform p40, p40-TIA-1, RNA binding protein TIA1, T-cell-restricted intracellular antigen-1 (TIA1), TIA-1, TIA1, TIA1 cytotoxic granule associated RNA binding protein, TIAL1, TIAR, WDM,TIA1 (T-Cell-Restricted Intracellular Antigen-1)
Cellular localisation: Cytoplasmic

Poids moléculaire: 40kDa

ID gène: 7072, 413123

UniProt: P31483