NMI anticorps

N° du produit ABIN7127126

Cet anticorps anti-NMI est un anticorps Souris Monoclonal détectant NMI dans FACS. Adapté pour Humain.

Aperçu rapide pour NMI anticorps (ABIN7127126)

Antigène: NMI (N-Myc (And STAT) Interactor (NMI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NMI est non-conjugé

Application: Flow Cytometry (FACS)

Détail du produit anti-NMI anticorps

Specificité: Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.

Réactivité croisée (Details): Human

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human NMI protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or K562 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur NMI

Antigène: NMI (N-Myc (And STAT) Interactor (NMI))

Autre désignation: NMI

Sujet: N myc (and STAT) interactor, N myc interactor, NMI, NMYC and STAT interactor, NMYC interactor,N myc (and STAT) Interactor / NMI
Cellular localisation: Nucleus.

Poids moléculaire: 38kDa

ID gène: 9111, 54483

UniProt: Q13287