NMI anticorps
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- Antigène Voir toutes NMI Anticorps
- NMI (N-Myc (And STAT) Interactor (NMI))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp NMI est non-conjugé
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Application
- Flow Cytometry (FACS)
- Specificité
- Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.
- Réactivité croisée (Details)
- Human
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human NMI protein
- Isotype
- IgG2b
- Top Product
- Discover our top product NMI Anticorps primaire
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- Indications d'application
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Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or K562 cells.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- NMI (N-Myc (And STAT) Interactor (NMI))
- Autre désignation
- NMI (NMI Produits)
- Synonymes
- anticorps fj02e01, anticorps wu:fj02e01, anticorps NMI, anticorps MGC108489, anticorps N-myc and STAT interactor, anticorps N-myc (and STAT) interactor, anticorps N-myc and STAT interactor L homeolog, anticorps NMI, anticorps Nmi, anticorps nmi, anticorps nmi.L
- Sujet
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N myc (and STAT) interactor, N myc interactor, NMI, NMYC and STAT interactor, NMYC interactor,N myc (and STAT) Interactor / NMI
Cellular localisation: Nucleus. - Poids moléculaire
- 38kDa
- ID gène
- 9111, 54483
- UniProt
- Q13287
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