QKI anticorps

N° du produit ABIN7127192

Cet anticorps anti-QKI est un anticorps Souris Monoclonal détectant QKI dans WB, IF, ELISA, IP et FACS. Adapté pour Humain.

Aperçu rapide pour QKI anticorps (ABIN7127192)

Antigène: QKI (Protein Quaking (QKI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp QKI est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Détail du produit anti-QKI anticorps

Specificité: QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human QKI protein

Isotype: IgG2

Information d'application

Indications d'application:

Known_Application: ELISA (concentration assay dependent), Flow Cytometry (1-2 μg/million cells),Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: U87, HeLa, K562 or MCF7 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur QKI

Antigène: QKI (Protein Quaking (QKI))

Autre désignation: QKI

Sujet: Homolog of mouse quaking QKI KH domain RNA binding protein, HQK1, Protein quaking, QK1, QK3, QKI, QKI1, Quaking homolog KH domain RNA binding mouse, Quaking isoform 1, Quaking protein, RNA binding protein HQK,QKI / Protein Quaking
Cellular localisation: Nucleus. Cytoplasm.

Poids moléculaire: 37.6kDa

ID gène: 9444, 510324

UniProt: Q96PU8