Recombinant XPO1 anticorps

N° du produit ABIN7127436

L’anticorps Lapin Monoclonal anti-XPO1 a été validé pour ELISA et IHC. Il convient pour détecter XPO1 dans des échantillons de Humain.

Aperçu rapide pour Recombinant XPO1 anticorps (ABIN7127436)

Antigène: XPO1 (Exportin 1 (XPO1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp XPO1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 9F2

Détail du produit anti-XPO1 anticorps

Fonction: XPO1 Recombinant Monoclonal Antibody

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human CRM1

Isotype: IgG

Information d'application

Indications d'application: IHC:1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur XPO1

Antigène: XPO1 (Exportin 1 (XPO1))

Autre désignation: XPO1

Sujet:

Background: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Aliases: Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog), XPO1, CRM1

UniProt: O14980

Pathways: M Phase