Recombinant LOXL2 anticorps

N° du produit ABIN7127602

Détail du produit anti-LOXL2 anticorps

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp LOXL2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris, Rat

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human LOXL2

Clone: 2E5

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200, FC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LOXL2

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Autre désignation: LOXL2 (LOXL2 Produits)

Synonymes: anticorps LOR2, anticorps WS9-14, anticorps CG4402, anticorps Dmel\\CG4402, anticorps Dmloxl-2, anticorps dmlox-2, anticorps 1110004B06Rik, anticorps 4930526G11Rik, anticorps 9430067E15Rik, anticorps GB13360, anticorps lox2-like, anticorps LOXL2, anticorps lor2, anticorps loxl-2, anticorps ws9-14, anticorps im:7136137, anticorps si:dkeyp-32b1.1, anticorps wu:fk12g04, anticorps zgc:158414, anticorps lysyl oxidase like 2, anticorps lysyl oxidase-like 2, anticorps lysyl oxidase homolog 4, anticorps lysyl oxidase like 2 L homeolog, anticorps lysyl oxidase-like 2b, anticorps LOXL2, anticorps lox2, anticorps Loxl2, anticorps LOC408544, anticorps loxl2.L, anticorps loxl2, anticorps loxl2b

Sujet:

Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Aliases: Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14), LOXL2

UniProt: Q9Y4K0

Pathways: Chromatin Binding