ADD2 anticorps

N° du produit ABIN7128257

Détail du produit anti-ADD2 anticorps

Antigène: ADD2 (Adducin 2 (Beta) (ADD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADD2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen affinity purification

Immunogène: Fusion protein of Human ADD2

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:1000-1:2000, IHC:1:15-1:50,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ADD2

Antigène: ADD2 (Adducin 2 (Beta) (ADD2))

Autre désignation: ADD2 (ADD2 Produits)

Synonymes: anticorps si:dkey-202n14.5, anticorps ADDB, anticorps 2900072M03Rik, anticorps add97, anticorps beta-ADD, anticorps adducin 2, anticorps adducin 2 (beta), anticorps ADD2, anticorps add2, anticorps Add2

Sujet:

Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

Aliases: ADD 2 antibody, ADD2 antibody, ADDB antibody, ADDB_HUMAN antibody, Adducin 2 (beta) antibody, Adducin2 antibody, Beta adducin antibody, Beta-adducin antibody, Erythrocyte adducin subunit beta antibody, OTTHUMP00000203378 antibody, OTTHUMP00000203908 antibody

UniProt: P35612

Pathways: Regulation of Actin Filament Polymerization