SPATA13 anticorps

N° du produit ABIN7131154

Détail du produit anti-SPATA13 anticorps

Antigène: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPATA13 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen affinity purification

Immunogène: Fusion protein of Human SPATA13

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SPATA13

Antigène: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Autre désignation: SPATA13 (SPATA13 Produits)

Synonymes: anticorps ARHGEF29, anticorps ASEF2, anticorps C79050, anticorps ESTM11, anticorps X83327, anticorps mFLJ00298, anticorps spermatogenesis associated 13, anticorps SPATA13, anticorps Spata13

Sujet:

Background: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

Aliases: APC-stimulated guanine nucleotide exchange factor 2 antibody, ARHGEF29 antibody, Asef2 antibody, FLJ31208 antibody, RP11-307N16.3 antibody, Spata13 antibody, Spermatogenesis-associated protein 13 antibody, SPT13_HUMAN antibody

UniProt: Q96N96