PDCD4 anticorps (pSer67)

N° du produit ABIN7138677

L’anticorps Lapin Polyclonal anti-PDCD4 a été validé pour WB et ELISA. Il convient pour détecter PDCD4 dans des échantillons de Humain.

Aperçu rapide pour PDCD4 anticorps (pSer67) (ABIN7138677)

Antigène: PDCD4 (Programmed Cell Death 4 (PDCD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDCD4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PDCD4 anticorps

Épitope: pSer67

Fonction: Phospho-PDCD4 (Ser67) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 67 (K-N-S(p)-S-R) derived from Human PDCD4 .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PDCD4

Antigène: PDCD4 (Programmed Cell Death 4 (PDCD4))

Autre désignation: PDCD4

Sujet:

Background:

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA

Kakade D, Islam N, Maeda N, Adegoke OA (2014)BMC Cell Biol 15, 2 . Dorrello NV, et al. (2006)Science 314, 467-71. Palamarchuk A, et al. (2005)Cancer Res 65, 11282-6.

Aliases: Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, MGC33046 antibody, MGC33047 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody, Nuclear antigen H731 like antibody, Nuclear antigen H731 like protein antibody, Nuclear antigen H731-like antibody, PDCD 4 antibody, Pdcd4 antibody, PDCD4_HUMAN antibody, Programmed cell death 4 antibody, programmed cell death 4 (neoplastic transformation inhibitor) antibody, Programmed cell death protein 4 antibody, Protein 197/15a antibody, Protein MA-3 antibody, Tis antibody, Topoisomerase-inhibitor suppressed protein antibody

UniProt: Q53EL6