PIN1 anticorps (pSer16)

N° du produit ABIN7138748

Cet anticorps Lapin Polyclonal détecte spécifiquement PIN1 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour PIN1 anticorps (pSer16) (ABIN7138748)

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PIN1 anticorps

Épitope: pSer16

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine16(R-M-S(p)-R-S) derived from Human Pin1 .

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIN1

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Autre désignation: PIN1

Sujet:

Background:

Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.

Lee YC, et al. (2013)J Cell Sci 126, 4862-72. Ando K, et al. (2013)Neurobiol Aging 34, 757-69. Nechama M, Lin CL, Richter JD (2013)Mol Cell Biol 33, 48-58.

Aliases: DOD antibody, DODO, Drosophila, homolog of antibody, FLJ40239 antibody, FLJ77628 antibody, MGC10717 antibody, NIMA interacting 1 antibody, Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody, Peptidyl prolyl cis/trans isomerase NIMA interacting antibody, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Peptidyl-prolyl cis-trans isomerase pin1 antibody, Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody, Pin 1 antibody, Pin1 antibody, PIN1_HUMAN antibody, PPIase Pin1 antibody, Prolyl isomerase antibody, Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody, Protein NIMA interacting 1 antibody, Rotamase Pin1 antibody, UBL 5 antibody, UBL5 antibody

UniProt: Q13526