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STK4 anticorps (pThr183)

STK4 Reactivité: Humain WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7138786
  • Antigène Voir toutes STK4 Anticorps
    STK4 (serine/threonine Kinase 4 (STK4))
    Épitope
    • 10
    • 10
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pThr183
    Reactivité
    • 51
    • 26
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 60
    • 4
    Lapin
    Clonalité
    • 60
    • 4
    Polyclonal
    Conjugué
    • 31
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp STK4 est non-conjugé
    Application
    • 54
    • 32
    • 29
    • 9
    • 9
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
     Réactivité croisée
    Humain, Souris
    Purification
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
    Immunogène
    Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2.
    Isotype
    IgG
    Top Product
    Discover our top product STK4 Anticorps primaire
  • Indications d'application
    WB:1:500-1:3000, IHC:1:50-1:100,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    STK4 (serine/threonine Kinase 4 (STK4))
    Autre désignation
    STK4 (STK4 Produits)
    Synonymes
    anticorps KRS2, anticorps MST1, anticorps TIIAC, anticorps YSK3, anticorps AI447339, anticorps AU020804, anticorps Kas-2, anticorps Mst1, anticorps Ysk3, anticorps krs2, anticorps mst1, anticorps ysk3, anticorps serine/threonine kinase 4, anticorps serine/threonine kinase 4 S homeolog, anticorps STK4, anticorps Stk4, anticorps stk4.S
    Sujet

    Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.

    Aliases: Kinase responsive to stress antibody, Krs2 antibody, Mammalian STE20 like protein kinase 1 antibody, Mammalian STE20-like protein kinase 1 antibody, Mammalian sterile 20 like 1 antibody, MST-1 antibody, MST1 antibody, Serine/threonine kinase 4 antibody, Serine/threonine protein kinase Krs 2 antibody, Serine/threonine-protein kinase 4 antibody, Serine/threonine-protein kinase Krs-2 antibody, STE20 like kinase MST1 antibody, STE20-like kinase MST1 antibody, STK4 antibody, STK4_HUMAN antibody, TIIAC antibody, YSK3 antibody

    UniProt
    Q13043
    Pathways
    Tube Formation
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