TNK2 anticorps (pTyr284)

N° du produit ABIN7138968

L’anticorps anti-TNK2 Polyclonal Lapin est utilisé pour la détection de TNK2 dans des échantillons de Humain. Il a été validé pour WB, ELISA, IHC et IF.

Aperçu rapide pour TNK2 anticorps (pTyr284) (ABIN7138968)

Antigène: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TNK2 anticorps

Épitope: pTyr284

Fonction: Phospho-TNK2 (Tyr284) Antibody

Réactivité croisée: Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y(p)-V-M) derived from Human ACK1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TNK2

Antigène: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Autre désignation: TNK2

Sujet:

Background:

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes.

Manser E., Nature 363:364-367(1993).
Ota T., Nat. Genet. 36:40-45(2004).
Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Aliases: Acetate kinase 1 antibody, Acetokinase 1 antibody, ACK 1 antibody, ACK antibody, ACK-1 antibody, ACK1 antibody, ACK1_HUMAN antibody, Activated Cdc42 associated kinase 1 antibody, Activated CDC42 kinase 1 antibody, Activated p21cdc42Hs kinase antibody, FLJ44758 antibody, FLJ45547 antibody, p21cdc42Hs antibody, TNK 2 antibody, TNK2 antibody, Tyrosine kinase non receptor 2 antibody, Tyrosine kinase non receptor protein 2 antibody, Tyrosine kinase non-receptor protein 2 antibody

UniProt: Q07912