RABAC1 anticorps (AA 16-299) (HRP)

N° du produit ABIN7140911

Cet anticorps Lapin Polyclonal détecte spécifiquement RABAC1 dans ELISA. Il présente une réactivité envers Candida albicans.

Aperçu rapide pour RABAC1 anticorps (AA 16-299) (HRP) (ABIN7140911)

Antigène: RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))

Reactivité: Candida albicans

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RABAC1 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-RABAC1 anticorps (HRP)

Épitope: AA 16-299

Fonction: PRA1 Antibody, HRP conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RABAC1

Antigène: RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))

Autre désignation: PRA1

Sujet:

Background: Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.

Aliases: PRA1 antibody, FBP1 antibody, CAALFM_C406980WA antibody, CaO19.10623 antibody, CaO19.3111 antibody, pH -regulated antigen PRA1 antibody, 58 kDa fibrinogen-binding mannoprotein antibody

UniProt: P87020

Pathways: Chromatin Binding