BotA (AA 1-436) anticorps

N° du produit ABIN7141048

Cet anticorps anti-BotA Polyclonal Lapin (ABIN7141048) détecte spécifiquement BotA dans ELISA. L’anticorps est réactif avec des échantillons de Clostridium botulinum.

Aperçu rapide pour BotA (AA 1-436) anticorps (ABIN7141048)

Antigène: BotA

Reactivité: Clostridium botulinum

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA

Détail du produit

Épitope: AA 1-436

Fonction: botA Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Clostridium botulinum Botulinum neurotoxin type A protein (1-436AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: BotA

Sujet:

Background: Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.

Aliases: botA antibody, atx antibody, bonTBotulinum neurotoxin type A antibody, BoNT/A antibody, Bontoxilysin-A antibody, BOTOX antibody, Botulinum neurotoxin type A1) [Cleaved into: Botulinum neurotoxin A light chain antibody, LC antibody, EC 3.4.24.69), Botulinum neurotoxin A heavy chain antibody, HC)] antibody

UniProt: P0DPI0