RNASEL anticorps (AA 330-741)

N° du produit ABIN7142130

Détail du produit anti-RNASEL anticorps

Antigène: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Épitope: AA 330-741

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNASEL est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human 2-5A-dependent ribonuclease protein (330-741AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RNASEL

Antigène: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Autre désignation: RNASEL (RNASEL Produits)

Synonymes: anticorps E230029I04Rik, anticorps PRCA1, anticorps RNS4, anticorps ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent), anticorps ribonuclease L, anticorps Rnasel, anticorps RNASEL

Sujet:

Background: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Aliases: 2 5A dependent ribonuclease antibody, 2 5A dependent RNase antibody, 2' 5' oligoisoadenylate synthetase dependent antibody, 2-5A-dependent ribonuclease antibody, 2-5A-dependent RNase antibody, DKFZp781D08126 antibody, Interferon induced 2 5A dependent RNase antibody, MGC104972 antibody, MGC133329 antibody, PRCA 1 antibody, PRCA1 antibody, Ribonuclease 4 antibody, Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) antibody, Ribonuclease L antibody, Ribonuclease4 antibody, RibonucleaseL antibody, RN5A_HUMAN antibody, RNase L antibody, Rnasel antibody, RNS 4 antibody, RNS4 antibody

UniProt: Q05823

Pathways: Hepatitis C