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DCLRE1B anticorps (AA 345-493)

DCLRE1B Reactivité: Humain ELISA, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7142656
  • Antigène Voir toutes DCLRE1B Anticorps
    DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
    Épitope
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    AA 345-493
    Reactivité
    • 27
    • 9
    • 1
    Humain
    Hôte
    • 26
    • 1
    Lapin
    Clonalité
    • 26
    • 1
    Polyclonal
    Conjugué
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DCLRE1B est non-conjugé
    Application
    • 18
    • 16
    • 13
    • 2
    • 1
    ELISA, Immunofluorescence (IF)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human 5' exonuclease Apollo protein (345-493AA)
    Isotype
    IgG
    Top Product
    Discover our top product DCLRE1B Anticorps primaire
  • Indications d'application
    Recommended dilution: IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
    Autre désignation
    DCLRE1B (DCLRE1B Produits)
    Synonymes
    anticorps APOLLO, anticorps SNM1B, anticorps SNMIB, anticorps im:6894074, anticorps zgc:154089, anticorps AI452214, anticorps Apollo, anticorps mSNM1B, anticorps DNA cross-link repair 1B, anticorps DCLRE1B, anticorps Dclre1b, anticorps dclre1b
    Sujet

    Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

    Aliases: DCLRE1B antibody, SNM1B5' exonuclease Apollo antibody, EC 3.1.-.- antibody, DNA cross-link repair 1B protein antibody, SNM1 homolog B antibody, SNMIB antibody, hSNM1B antibody

    UniProt
    Q9H816
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