ASIC1 anticorps (AA 195-297)

N° du produit ABIN7142996

Cet anticorps Lapin Polyclonal détecte spécifiquement ASIC1 dans WB, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour ASIC1 anticorps (AA 195-297) (ABIN7142996)

Antigène: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASIC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-ASIC1 anticorps

Épitope: AA 195-297

Fonction: ASIC1 Antibody

Réactivité croisée: Souris

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Acid-sensing ion channel 1 protein (195-297AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ASIC1

Antigène: ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))

Autre désignation: ASIC1

Sujet:

Background: Isoform 2 and isoform 3 function as proton-gated sodium channels, they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Aliases: ACCN2 antibody, ACCN2_HUMAN antibody, Acid sensing ion channel 1 antibody, Acid sensing ion channel 1a protein antibody, Acid sensing ion channel antibody, Acid-sensing ion channel 1 antibody, AI843610 antibody, Amiloride sensitive cation channel 2 neuronal antibody, Amiloride-sensitive cation channel 2 antibody, ASIC antibody, ASIC1 antibody, ASIC1A antibody, B530003N02Rik antibody, BNaC2 antibody, Brain sodium channel 2 antibody, Cation channel amiloride sensitive neuronal 2 antibody, hBNaC2 antibody, neuronal antibody

UniProt: P78348