FAM107A anticorps (AA 1-144)

N° du produit ABIN7143032

Cet anticorps Lapin Polyclonal détecte spécifiquement FAM107A dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour FAM107A anticorps (AA 1-144) (ABIN7143032)

Antigène: FAM107A (Family with Sequence Similarity 107, Member A (FAM107A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM107A est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FAM107A anticorps

Épitope: AA 1-144

Fonction: FAM107A Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Actin-associated protein FAM107A protein (1-144AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FAM107A

Antigène: FAM107A (Family with Sequence Similarity 107, Member A (FAM107A))

Autre désignation: FAM107A

Sujet:

Background: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization, negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580).

Aliases: Down regulated in renal cell carcinoma 1 antibody, Down-regulated in renal cell carcinoma 1 antibody, Downregulated in renal cell carcinoma antibody, DRR1 antibody, F107A_HUMAN antibody, FAM107A antibody, Family with sequence similarity 107, member A antibody, FLJ30158 antibody, FLJ45473 antibody, Protein FAM107A antibody, Protein TU3A antibody, TU3A antibody

UniProt: O95990