Adhesion G Protein-Coupled Receptor G1 (ADGRG1) (AA 26-216) anticorps

N° du produit ABIN7143399

L’anticorps anti-Adhesion G Protein-Coupled Receptor G1 Polyclonal Lapin est utilisé pour la détection de Adhesion G Protein-Coupled Receptor G1 dans des échantillons de Humain. Il a été validé pour ELISA, IHC et IF.

Aperçu rapide pour Adhesion G Protein-Coupled Receptor G1 (ADGRG1) (AA 26-216) anticorps (ABIN7143399)

Antigène: Adhesion G Protein-Coupled Receptor G1 (ADGRG1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit

Épitope: AA 26-216

Fonction: ADGRG1 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Adhesion G-protein coupled receptor G1 protein (26-216AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Adhesion G Protein-Coupled Receptor G1 (ADGRG1)

Autre désignation: ADGRG1

Sujet:

Background: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).

Aliases: 7 transmembrane protein with no EGF like N terminal domains 1 antibody, BFPP antibody, DKFZp781L1398 antibody, EGF TM7 like antibody, G protein coupled receptor 56 antibody, G-protein coupled receptor 56 antibody, GPR 56 antibody, Gpr56 antibody, GPR56_HUMAN antibody, Polymicrogyria bilateral frontoparietal antibody, Protein TM7XN1 antibody, TM7LN4 antibody, TM7XN1 antibody, TM7XN1 protein antibody

UniProt: Q9Y653