ALOX15 anticorps (AA 1-225)

N° du produit ABIN7144538

Cet anticorps Lapin Polyclonal détecte spécifiquement ALOX15 dans IHC, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour ALOX15 anticorps (AA 1-225) (ABIN7144538)

Antigène: ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALOX15 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-ALOX15 anticorps

Épitope: AA 1-225

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Arachidonate 15-lipoxygenase protein (1-225AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ALOX15

Antigène: ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Autre désignation: ALOX15

Sujet:

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

Aliases: 15 lipoxygenase 1 antibody, 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE antibody, 15 LOX antibody, 15 LOX 1 antibody, 15-LOX antibody, 15LOX 1 antibody, ALOX15 antibody, Arachidonate 15 lipoxygenase antibody, Arachidonate 15-lipoxygenase antibody, Arachidonate omega 6 lipoxygenase antibody, Arachidonate omega-6 lipoxygenase antibody, LOG15 antibody, LOX15_HUMAN antibody

UniProt: P16050

Pathways: Regulation of Actin Filament Polymerization