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BATF anticorps (Basic Leucine Zipper ATF-like Transcription Factor) AA 1-125 Primary Antibody

BATF Reactivité: Humain ELISA, IHC, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7145275
$328.90
Plus shipping costs $45.00
100 μg
local_shipping Destination: Etats-Unis
Envoi sous 10 à 13 jours ouvrables
  • Antigène Voir toutes BATF Anticorps
    BATF
    Épitope
    • 15
    • 15
    • 13
    • 8
    • 7
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-125
    Reactivité
    • 69
    • 11
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 55
    • 7
    • 7
    Lapin
    Clonalité
    • 65
    • 4
    Polyclonal
    Conjugué
    • 26
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BATF est non-conjugé
    Application
    • 39
    • 38
    • 13
    • 13
    • 10
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
     Réactivité croisée
    Humain, Souris
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA)
    Isotype
    IgG
  • Indications d'application
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    BATF
    Autre désignation
    BATF (BATF Produits)
    Synonymes
    B-ATF, si:ch211-153j24.4, BATF1, SFA-2, SFA2, basic leucine zipper transcription factor, ATF-like, basic leucine zipper ATF-like transcription factor, batf, BATF, Batf
    Sujet

    Background: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5\\\'-TGA[CG]TCA-3\\\'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5\\\'-TGAnTCA/GAAA-3\\\'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

    Aliases: Activating transcription factor B antibody, B ATF antibody, B-ATF antibody, B-cell-activating transcription factor antibody, Basic leucine zipper transcription factor like antibody, Basic leucine zipper transcriptional factor ATF like antibody, Basic leucine zipper transcriptional factor ATF-like antibody, Batf antibody, BATF_HUMAN antibody, BATF1 antibody, SF HT activated gene 2 protein antibody, SF-HT-activated gene 2 protein antibody, SFA 2 antibody, SFA-2 antibody, SFA2 antibody

    UniProt
    Q16520
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