Tel:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@anticorps-enligne.fr

BOK anticorps (BCL2-Related Ovarian Killer) AA 15-103 (HRP) Primary Antibody

BOK Reactivité: Humain ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN7145317
$328.90
Plus shipping costs $45.00
100 μg
local_shipping Destination: Etats-Unis
Envoi sous 10 à 13 jours ouvrables
  • Antigène Voir toutes BOK Anticorps
    BOK
    Épitope
    • 19
    • 16
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-103
    Reactivité
    • 55
    • 15
    • 7
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 53
    • 2
    Lapin
    Clonalité
    • 55
    Polyclonal
    Conjugué
    • 21
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BOK est conjugé à/à la HRP
    Application
    • 40
    • 38
    • 22
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Bcl-2-related ovarian killer protein (15-103AA)
    Isotype
    IgG
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    BOK
    Autre désignation
    BOK (BOK Produits)
    Synonymes
    BOK, bok, zgc:100979, zgc:64041, BCL2L9, BOKL, Bok-BH3, AI847676, AU021146, matador, mtd, BOK, BCL2 family apoptosis regulator, BCL2-related ovarian killer a, BCL2-related ovarian killer b, BCL2-related ovarian killer, BOK, boka, bokb, Bok
    Sujet

    Background: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apototic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).

    Aliases: Bcl 2 related ovarian killer protein antibody, Bcl-2-like protein 9 antibody, Bcl-2-related ovarian killer protein antibody, BCL2 related ovarian killer antibody, Bcl2-L-9 antibody, BCL2L9 antibody, BOK antibody, BOK_HUMAN antibody, BOKL antibody, Hbok antibody, MGC4631 antibody

    UniProt
    Q9UMX3
    Pathways
    Positive Regulation of Endopeptidase Activity
Vous êtes ici: