JMJD6 anticorps (AA 1-320)

N° du produit ABIN7145557

Cet anticorps anti-JMJD6 est un anticorps Lapin Polyclonal détectant JMJD6 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour JMJD6 anticorps (AA 1-320) (ABIN7145557)

Antigène: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMJD6 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-JMJD6 anticorps

Épitope: AA 1-320

Fonction: JMJD6 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur JMJD6

Antigène: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Autre désignation: JMJD6

Sujet:

Background: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at \\\'Arg-2\\\' (H3R2me) and histone H4 at \\\'Arg-3\\\' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

Aliases: Apoptotic cell clearance receptor antibody, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody, Histone arginine demethylase JMJD6 antibody, JmjC domain-containing protein 6 antibody, JMJD 6 antibody, JMJD6 antibody, JMJD6_HUMAN antibody, Jumonji domain containing 6 antibody, Jumonji domain-containing protein 6 antibody, KIAA0585 antibody, Lysyl-hydroxylase JMJD6 antibody, Peptide-lysine 5-dioxygenase JMJD6 antibody, Phosphatidylserine receptor antibody, Protein PTDSR antibody, PSR antibody, PTDSR 1 antibody, PTDSR antibody, PTDSR1 antibody

UniProt: Q6NYC1