ZNF207 anticorps (AA 206-463) (FITC)

N° du produit ABIN7145870

Cet anticorps Lapin Polyclonal détecte spécifiquement ZNF207 dans . Il présente une réactivité envers Humain.

Aperçu rapide pour ZNF207 anticorps (AA 206-463) (FITC) (ABIN7145870)

Antigène: ZNF207 (Zinc Finger Protein 207 (ZNF207))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNF207 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-ZNF207 anticorps (FITC)

Épitope: AA 206-463

Fonction: ZNF207 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ZNF207

Antigène: ZNF207 (Zinc Finger Protein 207 (ZNF207))

Autre désignation: ZNF207

Sujet:

Background: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Aliases: Zinc finger protein 207 antibody, ZN207_HUMAN antibody, ZNF 207 antibody, ZNF207 antibody

UniProt: O43670