CALHM1 anticorps (AA 202-346)

N° du produit ABIN7146297

L’anticorps Lapin Polyclonal anti-CALHM1 a été validé pour WB et ELISA. Il convient pour détecter CALHM1 dans des échantillons de Humain.

Aperçu rapide pour CALHM1 anticorps (AA 202-346) (ABIN7146297)

Antigène: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALHM1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CALHM1 anticorps

Épitope: AA 202-346

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CALHM1

Antigène: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Autre désignation: CALHM1

Sujet:

Background: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.

Aliases: CAHM1_HUMAN antibody, Calcium homeostasis modulator 1 antibody, Calcium homeostasis modulator protein 1 antibody, CALHM1 antibody, FAM26C antibody, Family with sequence similarity 26, member C antibody, MGC39514 antibody, MGC39617 antibody, OTTHUMP00000020413 antibody, Protein FAM26C antibody

UniProt: Q8IU99