MCU anticorps (AA 155-233)

N° du produit ABIN7146314

Cet anticorps Lapin Polyclonal détecte spécifiquement MCU dans ELISA, IHC et WB. Il présente une réactivité envers Humain.

Aperçu rapide pour MCU anticorps (AA 155-233) (ABIN7146314)

Antigène: MCU (Mitochondrial Calcium Uniporter (MCU))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCU est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-MCU anticorps

Épitope: AA 155-233

Fonction: MCU Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MCU

Antigène: MCU (Mitochondrial Calcium Uniporter (MCU))

Autre désignation: MCU

Sujet:

Background: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2, at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a \\\'fight-or-flight\\\' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).

Aliases: MCU antibody, C10orf42 antibody, CCDC109ACalcium uniporter protein antibody, mitochondrial antibody, HsMCU antibody, Coiled-coil domain-containing protein 109A antibody

UniProt: Q8NE86

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis