CALCOCO2 anticorps (AA 137-446)

N° du produit ABIN7146349

Détail du produit anti-CALCOCO2 anticorps

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Épitope: AA 137-446

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALCOCO2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CALCOCO2

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Autre désignation: CALCOCO2 (CALCOCO2 Produits)

Synonymes: anticorps CALCOCO2, anticorps MGC110205, anticorps wu:fj08c01, anticorps zgc:110205, anticorps DKFZp469D2219, anticorps NDP52, anticorps 2410154J16Rik, anticorps C77254, anticorps Ndp52, anticorps Ndp52l1, anticorps RGD1559974, anticorps calcium binding and coiled-coil domain 2, anticorps CALCOCO2, anticorps calcoco2, anticorps Calcoco2

Sujet:

Background: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).

Aliases: Antigen nuclear dot 52 kDa protein antibody, CACO2_HUMAN antibody, Calcium binding and coiled coil domain 2 antibody, Calcium binding and coiled coil domain containing protein 2 antibody, Calcium-binding and coiled-coil domain-containing protein 2 antibody, CALCOCO 2 antibody, CALCOCO2 antibody, MGC17318 antibody, NDP52 antibody, Nuclear domain 10 protein 52 antibody, Nuclear domain 10 protein antibody, Nuclear domain 10 protein NDP52 antibody, Nuclear domain protein 52 antibody, Nuclear dot protein 52 antibody, OTTHUMP00000218344 antibody, OTTHUMP00000218345 antibody, OTTHUMP00000218346 antibody, OTTHUMP00000218347 antibody, OTTHUMP00000218349 antibody, OTTHUMP00000218351 antibody

UniProt: Q13137