CARD9 anticorps (AA 237-536)

N° du produit ABIN7146924

L’anticorps Lapin Polyclonal anti-CARD9 a été validé pour WB, IHC et ELISA. Il convient pour détecter CARD9 dans des échantillons de Humain.

Aperçu rapide pour CARD9 anticorps (AA 237-536) (ABIN7146924)

Antigène: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-CARD9 anticorps

Épitope: AA 237-536

Fonction: CARD9 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Caspase recruitment domain-containing protein 9 protein (237-536AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CARD9

Antigène: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Autre désignation: CARD9

Sujet:

Background: Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

Aliases: CANDF2 antibody, CARD9 antibody, CARD9_HUMAN antibody, Caspase recruitment domain family member 9 antibody, Caspase recruitment domain-containing protein 9 antibody, hCARD9 antibody

UniProt: Q9H257

Pathways: Activation of Innate immune Response