CHMP2B anticorps (AA 1-213)

N° du produit ABIN7147523

Cet anticorps Lapin Polyclonal détecte spécifiquement CHMP2B dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour CHMP2B anticorps (AA 1-213) (ABIN7147523)

Antigène: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP2B est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-CHMP2B anticorps

Épitope: AA 1-213

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Charged multivesicular body protein 2b protein (1-213AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHMP2B

Antigène: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Autre désignation: CHMP2B

Sujet:

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Aliases: ALS17 antibody, Charged multivesicular body protein 2b antibody, CHM2B_HUMAN antibody, CHMP family, member 2B antibody, CHMP2.5 antibody, CHMP2b antibody, Chromatin modifying protein 2b antibody, Chromatin-modifying protein 2b antibody, DMT1 antibody, hVps2-2 antibody, Vacuolar protein sorting 2, yeast, homolog of, B antibody, Vacuolar protein sorting 2-2 antibody, Vacuolar protein sorting-associated protein 2-2 antibody, VPS2 homolog B antibody, Vps2-2 antibody, VPS2B antibody

UniProt: Q9UQN3