CHMP4B anticorps (AA 1-224)

N° du produit ABIN7147524

L’anticorps Lapin Polyclonal anti-CHMP4B a été validé pour IHC et ELISA. Il convient pour détecter CHMP4B dans des échantillons de Humain.

Aperçu rapide pour CHMP4B anticorps (AA 1-224) (ABIN7147524)

Antigène: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP4B est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-CHMP4B anticorps

Épitope: AA 1-224

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Charged multivesicular body protein 4b protein (1-224AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHMP4B

Antigène: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Autre désignation: CHMP4B

Sujet:

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: Charged multivesicular body protein 4b antibody, CHM4B_HUMAN antibody, chmp4b antibody, Chromatin-modifying protein 4b antibody, hSnf7-2 antibody, hVps32-2 antibody, SNF7 homolog associated with Alix 1 antibody, SNF7-2 antibody, Vacuolar protein sorting-associated protein 32-2 antibody, Vps32-2 antibody

UniProt: Q9H444