CHTOP anticorps (AA 179-248)

N° du produit ABIN7147689

L’anticorps Lapin Polyclonal anti-CHTOP a été validé pour WB, ELISA et IHC. Il convient pour détecter CHTOP dans des échantillons de Humain.

Aperçu rapide pour CHTOP anticorps (AA 179-248) (ABIN7147689)

Antigène: CHTOP (Chromatin Target of PRMT1 (CHTOP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHTOP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-CHTOP anticorps

Épitope: AA 179-248

Fonction: CHTOP Antibody

Réactivité croisée: Souris

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Chromatin target of PRMT1 protein (179-248AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHTOP

Antigène: CHTOP (Chromatin Target of PRMT1 (CHTOP))

Autre désignation: CHTOP

Sujet:

Background: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).

Aliases: C1orf77 antibody, chromatin target of chromatin target of PRMT1 protein antibody, Chromatin target of PRMT1 antibody, Chromatin target of PRMT1 protein antibody, Chromosome 1 open reading frame 77 antibody, CHTOP antibody, CHTOP_HUMAN antibody, DKFZp547E1010 antibody, FL- RP1-178F15.2 antibody, FL-SRAG antibody, FOP antibody, Friend of PRMT1 antibody, Friend of PRMT1 protein antibody, HT031 antibody, MGC131924 antibody, MGC86949 antibody, OTTHUMP00000035122 antibody, OTTHUMP00000035123 antibody, Pp7704 antibody, RP1 178F15.2 antibody, Small arginine- and glycine-rich protein antibody, Small protein rich in arginine and glycine antibody, SRAG antibody, SRAG-3 antibody, SRAG-5 antibody

UniProt: Q9Y3Y2