BHLHE40 anticorps (AA 184-302) (HRP)

N° du produit ABIN7147840

Cet anticorps anti-BHLHE40 est un anticorps Lapin Polyclonal détectant BHLHE40 dans ELISA. Adapté pour Humain.

Aperçu rapide pour BHLHE40 anticorps (AA 184-302) (HRP) (ABIN7147840)

Antigène: BHLHE40 (Basic Helix-Loop-Helix Family, Member E40 (BHLHE40))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BHLHE40 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-BHLHE40 anticorps (HRP)

Épitope: AA 184-302

Fonction: BHLHE40 Antibody, HRP conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Class E basic helix-loop-helix protein 40 protein (184-302AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BHLHE40

Antigène: BHLHE40 (Basic Helix-Loop-Helix Family, Member E40 (BHLHE40))

Autre désignation: BHLHE40

Sujet:

Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

Aliases: BHE40_HUMAN antibody, bHLHB2 antibody, bHLHe40 antibody, Class B Basic Helix Loop Helix Protein 2 antibody, Class B basic helix-loop-helix protein 2 antibody, Class E basic helix loop helix protein 40 antibody, Class E basic helix-loop-helix protein 40 antibody, Clast5 antibody, DEC1 antibody, Differentially expressed in chondrocytes protein 1 antibody, E47 interaction protein 1 antibody, EIP1 antibody, Enhancer of split and hairy related protein 2 antibody, Enhancer-of-split and hairy-related protein 2 antibody, SHARP 2 antibody, SHARP-2 antibody, Stimulated by retinoic acid gene 13 protein antibody, STRA13 antibody

UniProt: O14503

Pathways: Photoperiodism