Cullin 4B anticorps (AA 1-200)

N° du produit ABIN7148757

L’anticorps Lapin Polyclonal anti-Cullin 4B a été validé pour ELISA et IHC. Il convient pour détecter Cullin 4B dans des échantillons de Humain.

Aperçu rapide pour Cullin 4B anticorps (AA 1-200) (ABIN7148757)

Antigène: Cullin 4B (CUL4B)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 4B est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-Cullin 4B anticorps

Épitope: AA 1-200

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Cullin-4B protein (1-200AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Cullin 4B

Antigène: Cullin 4B (CUL4B)

Autre désignation: CUL4B

Sujet:

Background: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

Aliases: CUL 4B antibody, CUL-4B antibody, CUL4B antibody, CUL4B_HUMAN antibody, Cullin-4B antibody, DKFZp686F1470 antibody, KIAA0695 antibody, MRXHF2 antibody, MRXSC antibody, SFM2 antibody

UniProt: Q13620