BMX anticorps (AA 65-280)

N° du produit ABIN7149358

Cet anticorps anti-BMX est un anticorps Lapin Polyclonal détectant BMX dans IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour BMX anticorps (AA 65-280) (ABIN7149358)

Antigène: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMX est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-BMX anticorps

Épitope: AA 65-280

Fonction: BMX Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Cytoplasmic tyrosine-protein kinase BMX protein (65-280AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BMX

Antigène: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Autre désignation: BMX

Sujet:

Background: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells, as well as in signal transduction in endocardial and arterial endothelial cells.

Aliases: Bmx antibody, BMX non receptor tyrosine kinase antibody, BMX_HUMAN antibody, BONE MARROW KINASE, X-LINKED antibody, Bone marrow tyrosine kinase gene in chromosome X protein antibody, Cytoplasmic tyrosine protein kinase BMX antibody, Cytoplasmic tyrosine-protein kinase BMX antibody, Epithelial and endothelial tyrosine kinase antibody, ETK antibody, NKT38 antibody, NTK 38 antibody, NTK38 antibody, Protein tyrosine kinase BMX antibody, PSCTK 2 antibody, PSCTK 3 antibody, PSCTK2 antibody, PSCTK3 antibody

UniProt: P51813